semaglutide injection bubble under skin What causes ozempic marks? Understanding Injection Site Reactions with

Sublingual semaglutide is a compounded formulation, not the same as the FDA-approved oral semaglutide tablet (Rybelsus) that Novo Nordisk manufactures

This is particularly helpful after meals when blood sugar levels are already elevated

doi:10.1002/jcsm.13524 7

23 April 2025 A Correction to this paper has been published: Abbreviations BBB: Bloodbrain barrier CNS: Central Nervous System GFAP: Glial fibrillary acidic protein GLP-1R: Glucagon-like peptide-1 receptor HFD: Highfat diet IB4: Biotinylated isolectin B4 Iba-1: Ionized calciumbinding adaptor molecule-1 ND: Normolipid diet NVU: Neurovascular unit SAL: Saline solution SEMA: Semaglutide References Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C

People report nausea, vomiting, constipation, abdominal pain, and diarrhea