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GLP-1 has a very brief half-life (less than 2 min) owing to the swift deactivation of the commonly proteolytic enzyme dipeptidyl peptidase-4 (DPP-4), which leads to the emergence of GLP-1 receptor agonists (GLP-1RAs), which are GLP-1 analogs with extended half-lives and ongoing biological activity (Ma et al

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