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The study found that pre-operative fasting for 3 days reduced infarct volume in rats with severe focal stroke, and the neuroprotection was associated with the regulation of innate immunity: elevated circulating neutrophil chemokine ligand 1 before ischemia and reduced pro-inflammatory markers (TNF- and its receptor, as well as downstream intercellular adhesion molecule-1) in the striatum after reperfusion

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This enhanced bioavailability makes these injections particularly effective for individuals following reduced-calorie diets

doi: 10.5664/jcsm.8438 54

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