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Moreover, here we used the standard 20S proteasome, which was previously found to have a reduced ability to degrade oxidized proteins in comparison to the immuno- and intermediate 20S proteasomes (i.e., complexes that contain a mixture of standard and inducible proteasome subunits) (Abi Habib et al, 2020)
The positive circuit of NF-B activation and ROS production can accumulate more ROS in irradiated OSCC cells and this positive feedback regulation overcomes the pro-survival effect of NF-B/IL-6 signaling (90)
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For instance, in May 2026, according to the National Library of Medicine, China is facing a growing obesity crisis, with predictions showing that by 2030, 70.5% of adults and 31.8% of children may be obese
