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Biological biomolecules based on gene expression, epigenetic alterations, microRNA profiles, protein phosphorylation and cytokine signatures can contribute to the selection of subsets of these patients for specific natural agents, monitoring in vivo biological efficacy and potential synergistic (or antagonistic) interactions with medical therapies (223)
For example, mitochondrial ATP is essential for sympathetic and parasympathetic nerve firing, and mitochondrial ROS modulate baroreflex sensitivity
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