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The formation of guanidinoacetate (GAA) from these two amino acids is catalyzed by the enzyme glycine amidinotransferase, also called L-arginine:glycine amidinotransferase (AGAT)

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The proactive arm governs proteome production and maturation, translation, co-translational quality control, chaperone-assisted folding, trafficking, and compartment-specific targeting, thereby limiting the generation of metastable or mislocalized proteins (Fig