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Additionally, the pocket normally occupied by the conserved phenylalanine residue of the TIN2 F-X-L-X-P motif was fully obstructed by a crystal contact with a TRF1 TRFH copy in an adjacent asymmetric unit, further limiting the possibility of obtaining XChem hits outside of the leucine pocket

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While berberine may offer modest metabolic benefits, it works through different mechanisms and produces smaller glycemic improvements than prescription GLP-1 medications, which remain the evidence-based standard of care

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