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Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)

Alexandria J Veterinary Sci 56(1) El Henafy HM, Ibrahim MA, Abd El Aziz SA, Gouda EM (2020) Oxidative Stress and DNA methylation in male rat pups provoked by the transplacental and translactational exposure to bisphenol A

Elimination is considered to be Phase 3 of detoxification

The United Kingdom follows at 5.1% , driven by rising adoption of fat-burning and plant-based formulations

Each capsule includes silymarin (milk thistle seed extract), artichoke leaf extract, turmeric root extract, methionine, choline, inositol, garlic and dandelion root extract