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The sodium chloride does not prevent bacterial growth

, NNMT

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

As their use has expanded, questions about cardiovascular safety have naturally emerged, particularly given that obesity itself is a major risk factor for heart disease

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