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Traditional peptides like insulin or GLP-1 agonists have near-zero oral bioavailabilityproteases in the stomach and small intestine cleave peptide bonds within minutes, and what little survives is metabolised by cytochrome P450 enzymes in the liver before reaching systemic circulation

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Learning and memory improvement and neuroprotection of Gardenia jasminoides (fructus gardenia) extract on ischemic brain injury rats