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By contrast, those with established cardiovascular disease already on aspirin are described as typically safe to begin GLP-1 therapy

You should contact your healthcare provider promptly if you experience any of the following: Severe or worsening abdominal pain Bloating that does not improve after 2-3 weeks Significant distress or interference with daily activities Signs of dehydration, such as dizziness, dark urine, or reduced urination Signs of a possible allergic reaction (rash, swelling of face/throat, difficulty breathing) Bloating accompanied by persistent vomiting or inability to keep fluids down Long-term outlook The majority of patients find that bloating eases within 48 weeks as their bodies get used to the medication

It is a spectrum

Healthline spoke with Mir Ali, MD, a board certified bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA

Table of Contents: What should I expect during the first week after my first Wegovy shot