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Ninety minutes after tablet administration, dogs received an oral glucose bolus (200 mg/mL at a 5 mL/kg volume calculated on body weight prior to HFHF feeding), and blood glucose (blood collected via peripheral vein) was measured with an AlphaTRAK glucometer system (Zoetis, Parsippany, NJ, USA) at 90, 0, 10, 20, 30, 40, 50, 60, 75, 90, 120, 180 and 240 min after glucose administration

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The standard titration schedule starts at 0.25 mg weekly and increases every 4 weeks to a maintenance dose of 1.52.5 mg, with adjustments based on individual tolerance and response

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