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More effort is required to elucidate underlying mechanisms of action and to develop and validate biomarkers of pharmacodynamic action in humans

[DOI] [PubMed] [Google Scholar] 49.Ahsan H

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This results in abnormal metabolism of carbohydrates and increased glucose levels, which, in turn, can promote increased intracellular glucose metabolism, leading to oxidative stress (Ding et al., 2007), kallikrein-bradykinin activation (Campbell et al., 2010), and secretion of inflammatory cytokines (Nishikawa et al., 2000)