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Liyanage-Don N, Fung D, Phillips E, Kronish IM

New bone may develop around the site where the tendon is attached to the forearm bone

In case of poor results with methylfolate, either mega doses of methlfolate should be given (up to 15 mg were used in studies) to provide sufficient methyl groups or SAM can be given directly

Severe nausea requiring treatment discontinuation was rare in monotherapy trials, with only about 1% of participants in the REDEFINE 1 trial stopping treatment because of adverse events overall

The locations of the mutations are shown as colored spheres and are predominantly found at the interface between protomers