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Studies also show that insulin alone cannot effectively manage diabetes because it doesn't address glucagon's catabolic effects, whereas treatments targeting glucagon suppression, such as leptin or glucagon receptor antibodies, could lead to better glucose regulation

Changes in the blood concentrations of specific acylcarnitines in subjects with either subjective memory complaints, mild cognitive impairment, or Alzheimer's disease, compared to cognitively healthy peers may reflect changes in the transport of fatty acids into the mitochondria and/or impairments in energy production

Jun 2011;133:581-593

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We walk through the biology that makes GLP-1RAs a plausible therapeutic in HS, the study's contributions, and the important questions that prospective studies will still need to answer