"Glutathione Deficiency during Early Postnatal Development Causes Schizophrenia-Like Symptoms and a Reduction in BDNF Levels in the Cortex and Hippocampus of Adult SpragueDawley Rats"
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AMPK synergizes with the combined treatment of 1-acetoxychavicol acetate and sodium butyrate to upregulate phase II detoxifying enzyme activities
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Preclinical models demonstrate that these compounds reduce reactive oxygen species, stabilize mitochondrial membrane potential, enhance mitophagy, and activate NRF2 dependent transcription, which translates into attenuation of ASD like behaviors in VPA, propionic acid, maternal immune activation, and BTBR paradigms (De Mattos et al., 2020
