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Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis

Surface characteristics such as charge, hydrophobicity, and functionalization with polymers or targeting ligands can modulate protein adsorption patterns, thereby affecting the biological identity of nanoparticles in vivo ( Cross-linking agents such as carbodiimide promote the covalent attachment of ligands to particle surfaces, enhancing their biocompatibility and efficacy in associating nanoparticles with specific ligands

The risk factors for diabetic peripheral neuropathy: a meta-analysis

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were the first to describe increased whole gut permeability in patients with alcohol abuse without significant liver disease, measured by a 24 h urinary excretion of 51 Cr-EDTA, which was confirmed by increased uptake of macromolecules (inulin, EDTA and cyanocobalamin) ex vivo in jejunal biopsies (145)