Though melatonin is known as a hormone that helps synchronize sleep-wake cycles, it has also been shown to be produced in the digestive tract in quantities far larger than in the brain (Bubenik 2002)
NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models
FSP1 (ferroptosis suppressor protein 1) facilitates the NADPH-dependent reduction of CoQ10 to CoQ10H 2 , a lipophilic radical-trapping antioxidant that prevents lipid peroxidation (Doll et al., 2019)
If toxic compounds are ingested in large amount, the glutathione stores are depleted
Van Buren JM, Wood JH, Oakley J, Hambrecht F