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Gradual dose reduction allows receptor density to adjust incrementally rather than experiencing a sharp signal drop that triggers compensatory suppression

In the low-grade systemic inflammation associated with obesity, interferon-gamma (IFN-) secreted by CD4+ and CD8+ lymphocytes can activate STAT1 in adipocytes, leading to dysfunctional adipocyte function and insulin resistance (44)

Furthermore, copper stimulates acute-phase proteins and activates the pro-inflammatory transcription factor NF-B via ROS generation

References Bendotti, G., Montefusco, L., Lunati, M

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