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Research indicates that ceasing GLP-1 medications 3 to 5 days prior to surgery still posed a risk for delayed wake-up, whereas a 14-day hiatus before significant operations such as total joint replacements is ideal to reduce the chance of retained stomach contents and anesthesia issues

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Tirzepatide (Zepbound, 15 mg weekly), SURMOUNT-1, 72 weeks: mean weight loss approximately 22.5%