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Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

In ALC, intrahepatic monocytes/macrophages are markedly expanded while adaptive immune cells, particularly B and plasma cells, are reduced and metabolically altered, consistent with alcohol-driven myeloid dominance and impaired humoral immunity

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For the vast majority of peptides, there are no adequate human safety studies in pregnancy, and the precautionary principle applies

Similarly, endometriosis in both patients and animal models is associated with elevated ROS in follicular fluid, NLRP3 inflammasome activation, GC pyroptosis, and loss of follicular integrity, collectively impairing oocyte maturation and fertility [71]