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The FDA labeling explicitly prohibits intramuscular or intravenous administration, as these routes were not studied in clinical trials

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GLP-1 receptor agonists like semaglutide slow your stomach and reduce hunger signals in your brain, causing rapid shifts in how your body processes food and energy

The subcutaneous layer at the abdomen becomes thinner as fat is lost, and a needle that was appropriate at a higher body weight may become too long as treatment progresses