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These pathogens disrupt oxidative phosphorylation, elevate mitochondrial ROS, and alter mitochondrial dynamics, leading to depolarized membrane potential and mtDNA release (Maekawa et al., 2019)

Nat Commun 9, 689

This helps reduce muscle fatigue and improve skin hydration

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A related glutaminase synthase inhibitor, IACS-6274, demonstrated clinical efficacy in overcoming cisplatin-resistance in an NRF2-active HNSCC xenograft model [85]