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No comparative data exist to determine whether this offers any advantage over single-route dosing

242 PKC activation enhances excitatory currents in the dorsal horn and trigeminal neurons, contributing to nociceptive hypersensitivity in DPN

In particular, experimental studies have demonstrated that manipulation of the gut microbiota can influence endogenous GLP-1 secretion and metabolic outcomes, indicating a mechanistic role for hostmicrobe interactions under controlled preclinical models (43)