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Description

[74] Vyas A, Hahm E, Arlotti J, et al

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2025 Apr 2;10(6):1980-1992

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We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors

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It may also increase the risk of certain types of cancer, such as Hodgkins Lymphoma [4]

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