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Manganese-induced parkinsonism and Parkinsons disease

Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain

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Together, these results show that the decrease of DUB activity temporally precedes proteasome inhibition in the aging mouse brain, and that chronic impairment of DUBs in neurons leads to partial inhibition of proteasome activity

Acute injury and/or neurodegenerative disease processes may weaken BBB integrity and allow the entry of blood products into the CNS compartment and stimulate microglial activation