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Future studies will need to clarify whether any signal differs by menopausal status, endocrine therapy exposure, obesity phenotype, tumor subtype, or duration and timing of GLP-1 receptor agonist use

Others relate to proteostasis, the maintenance of proper protein folding and function

However, reduced fluid intake, digestive side effects, and rapid weight loss may indirectly increase the risk in some individuals, making hydration an important part of treatment

Nofreezing reconstituted peptides causes ice crystal formation that physically disrupts peptide structure and reduces bioactivity by 4060%