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These reactions are spatially confined to the injection area and temporally related to the injection event, usually appearing within hours to days after administration and resolving spontaneously within several days

Water molecules attack the peptide bonds that link amino acids together, breaking the molecule into fragments

However, the degree of degradation depends on multiple factors including how far past expiration the medication is, storage conditions prior to and after expiration, and whether the product has been opened or remains sealed

It slows gastric emptying, reduces appetite, and helps regulate blood sugar

When it launched in the US, the manufacturer listed the starting dose of 1.5mg at $149 (around 110) a month