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The vast majority of absorbed ethanol (approximately 9098%) is oxidized in the liver, where high ADH and aldehyde dehydrogenase activities ensure systemic clearance, whereas only a minor fraction is metabolized directly within the brain [2,8,9,22]

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Another point is the modest in vitro-activity of eCATH-3, especially under physiological salt concentrations, even though the peptide is present at high levels in vivo