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It reflects the natural pharmacokinetic curve of a drug with a 5-day half-life dosed every 7 days

When results fall in this borderline range, a methylmalonic acid test is recommended to confirm whether a functional deficiency exists

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In addition to the phenomenon merely being symptomatic of drug-related kidney dysfunction and impaired renal ability to adequately excrete free water, hyponatremia can impact other physiological processes, resulting in significant mental-status changes, seizures, coma, etc