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CagriSema treatment resulted in substantially greater and clinically meaningful weight loss (-20.4%) than semaglutide alone (-14.9%), cagrilintide alone (-11.5%), or placebo (-3.0%), a finding consistent with at least partial additivity, although the study design does not permit a formal assessment of additive or synergistic effects

We administered saline plus vehicle (control) and RSL3 or 5-FU alone and in combination (i.e., 5-FU plus RSL3)

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