Unlike natural ageing, the Ozempic Face has manifested in a much younger patient cohort, as characterised by loss of fat, elastin and collagen, muscle atrophy, and excessive skin laxity, leading to changes in facial contours and overall appearance.[iv] The aesthetic sector is responding by offering cosmetic treatments to patients as a solution to restore volume, manage excess skin, and mitigate the hollowed facial appearance with dermal fillers, energy-based skin-tightening, and surgical intervention
10 This is especially important as GLP-1 receptor agonists confer multiple benefits for patients with diabetes, including better glucose control and weight loss
Even in the simplest case, these patients could experience mild adverse effects which can escalate into serious health conditions
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Finally, medications whose CVOTs result in the upper bound falling below 1.3 may be approved without the need for further documentation of CV safety in post-marketing studies ( Figure 3 )