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As a result, short-acting compared to long-acting GLP-1RAs are less effective in reducing fasting glucose and improving overall glucose control but are more effective in delaying gastric emptying and reducing glycemic excursion after meal ingestion (67)

This distinction matters clinically: preserved muscle maintains resting metabolic rate, improves body composition aesthetics, and supports long-term weight stability by preventing the metabolic adaptation that often follows muscle loss

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