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The dichloroquinoxaline group extends to ICL3 forming nonpolar interactions with K346 6.35b , C347 6.36b and a cholesterol molecule in TM6, introduction of electron-donating substituents or replacement of quinoxalines by benzimidazole or quinoline at C-6 and C-7 positions led to poor tolerance 38

3-Methylcrotonylglycinuria 3-Methylcrotonylglycinuria is a disorder of leucine catabolism that results from defects in either of the two subunits of the biotin-requiring enzyme, 3-methylcrotonyl-CoA carboxylase (3MCC)

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[1] [2] Patients should be counseled to report symptoms suggestive of thyroid tumors, including neck mass, dysphagia, hoarseness, or persistent dyspnea

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