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A key mechanism involves their interaction with glial cells, as recent studies show that activated microglia and astrocytes can induce the expression of GLP-1 R, making them direct targets for GLP-1 mimetics [41]

Serious and Rare Side Effects to Watch For Keeping an eye out for possible serious and rare side effects is important for people who use semaglutide

But this was unlikely to be a GLP-1 effect, since rather than GLP-1 driving lower food intake, lower food intake appeared to drive lower GLP-1

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