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Zinc dysregulation within the endolysosomal system also intersects with cancer biology: the alcohol-deterrent and emerging anticancer agent disulfiram disrupts endolysosomal structure and raises intraluminal zinc in breast cancer cells, implicating zinc dysregulation in its cytotoxicity and suggesting that extracellular zinc availability modulates its efficacy 169

Research Overview Melanotan II is a cyclic lactam heptapeptide analogue of alpha-melanocyte-stimulating hormone with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH

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doi: 10.1007/s00418-008-0437-4 108

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