is trulicity semaglutide or tirzepatide a vs. for weight loss—what's the difference? 🤔Both have What's the Difference Between Semaglutide

Activates GHRH receptors in the pituitary, prompting natural pulsatile release of endogenous growth hormone

Given the rising use of GLP-1 RAs for weight loss, clinicians should be vigilant in screening for otolaryngologic side effects, especially PET, in this population

The backstory: CVS Caremark, the nations largest pharmacy benefit manager, stopped covering Zepbound on July 1, 2025, after reaching a deal with Novo Nordisk, the maker of rival GLP-1 drug Wegovy

10.1038/srep25881 10 ChandlerJ

Other GLP-1s like Ozempic and Mounjaro are sometimes prescribed off-label for weight loss, though off-label prescriptions are unlikely to be covered by insurance