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VHL ubiquitinates glucose-6-phosphate dehydrogenase (G6PD) at K366 and K403, resulting in increased degradation of G6PD by the proteasome

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The variations in the signal (s) region and in the mid (m) greatly influence the effects of VacA, especially the s region variation which is associated with the vacuolating activity of VacA, whereas the m region of VacA determines the cell specificity of vacuolation by affecting the binding of VacA to the host cells

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