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Advertisement Mean body weight loss in the semaglutide group at 104 weeks was 9.39% (versus 0.88% in the placebo group)

For tirzepatide, the average weight loss is 8.31 pounds in the first month, (not even a pound greater than semaglutide), 15.73 pounds over the first two months (almost three pounds more than semaglutide), 19.34 pounds over the first three months (a pound greater than semaglutide) and 26.40 pounds over the first four months (three pounds more than semaglutide)

Metabolic adaptation : The body naturally adapts to weight loss by reducing metabolic rate, a phenomenon sometimes called "adaptive thermogenesis." This biological response is expected and can slow or plateau weight loss even when medication and lifestyle factors remain consistent

The populations were matched by sex, height, weight, race, ethnicity, social vulnerability index (SVI), and age

Average weight loss after 12 weeks: Up to 6% By the 12-week mark, you could lose up to 6% of your body weight [1]