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The antibody simtuzumab, targeting extracellular LOXL2, has undergone clinical trials in combination with gemcitabine for patients with metastatic pancreatic adenocarcinoma or with FOLFIRI (folinic acid, fluorouracil, and irinotecan) for patients with KRAS mutant colorectal cancer [102, 103]

12,19-21 It is also possible that migraine-associated and nonmigraine CVS are two entirely different disorders with different pathophysiologies

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(10) Other studies have backed up these findings