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Treatment of SOD-G93A transgenic ALS mice with TSA ameliorated muscle atrophy and neuromuscular junction denervation (Yoo and Ko, 2011)

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This finding is particularly noteworthy given that some trials extended to 24 weeks of continuous exposure and included participants with obesity-related comorbidities who might be expected to have higher baseline health risks

Histopathology revealed decreased expressions of TNF- and TGF-, inflammatory markers and fibrotic mediators