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Indeed, the use of GLP-1 agonists has already created shortages, particularly because impressive weight reduction continues to be shown with their use. Because of their side-effect profiles and mechanisms of action, these drugs raise questions about long-term treatment adherence, as well as weight regain after they are discontinued
To date, two incretin hormones have been discovered: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) [2]
Real-world evidence from Sweden The clinical findings are supported by a thorough analysis of Swedish health records spanning nearly two decades
However, clinical studies with liraglutide have shown that this effect is generally modest and does not significantly impact the efficacy of most medications tested, including paracetamol and oral contraceptives
In adults with type 2 diabetes and obesity, a 48-week phase II trial demonstrated increased lean mass, reduced fat mass and glycemic improvement [64]
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