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A drug that extends median overall survival from 18 months to 26 months in a population with no approved second-line therapy commands fundamentally different pricing than one that achieves similar PFS gains in a market with four existing options

Isothermal titration calorimetry All ITC experiments were carried out at a constant temperature of 298 K using a PEAQ-ITC instrument from Malvern Analytical

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Once the initial phase is complete, most patients transition to a maintenance plan that ranges from once every one to two weeks, or sometimes monthly, depending on individual response and wellness goals