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ZhouWXuJLiHXuMChenZJWeiWet al
The superimposition of these two effects enhances the anti-apoptotic effect and reduces the dosage requirement of a single component, providing a potential solution for adjuvant therapy to cisplatin chemotherapy, reducing side effects and improving the quality of life of patients ( Despite their low bioavailability, oral polyphenols can modulate the intestinal flora through their antimicrobial properties, increasing the proportion of beneficial bacteria in the gut and reducing pathogenic bacteria ( 5 Conclusion Cisplatin is a highly effective and broad-spectrum anticancer drug, but its severe ototoxicity limits its clinical application, and its mechanism involves various pathways such as DNA damage, oxidative stress, inflammatory response, mitochondrial dysfunction, and ferroptosis
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It is suspended in a thick castor oil vehicle that holds a large 4 mL volume of medication
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