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Bath application of GLP-1 induces a depolarization in most hippocampal neurons and a hyperpolarization in a few neurons ( in vitro electrophysiological recordings further demonstrated that exendin-4 elicits an early fast excitatory response dose-dependently ( via increasing neuronal survival in the CA1, CA3, and DG regions of hippocampus (Zhang et al., 2021)

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Research also discusses effects on growth-factor signaling and collagen organization, which are relevant to connective tissue remodeling

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The sociability scores were calculated as: social motivation score = exploration of stranger/(total exploration in phase 1) and social recognition score = exploration of novel rat/(total exploration in phase 2)