From a pharmacological standpoint, several considerations are relevant: Gastrointestinal effects : Retatrutide, like other GLP-1-based therapies, commonly causes nausea, vomiting, diarrhoea, and reduced appetite
Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al
NICE-approved options include orlistat for adults with BMI 30 kg/m (or 28 kg/m with comorbidities), injectable semaglutide (Wegovy) for eligible patients with BMI 35 kg/m (or 30 kg/m with weight-related comorbidities), and liraglutide (Saxenda) where commissioned by local NHS services
Clinical and Practical Considerations Diabetes providers familiar with GLP1 agonists like semaglutide and liraglutide must now consider broader eligibility
During these shortages, legitimate compounding pharmacies like ours have stepped up to ensure continuity of care for patients who might otherwise go without