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Moreover, the common side-effect of GLP1R agonists in producing nausea is attributed to GLP1R-expressing neurons in the Area Postrema [20] , which is well known to regulate processes such as vomiting in humans

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B.LEADER Publication Committee on behalf of the LEADER Trial Investigators (2019)

To move to an earlier day in the week, take your next dose on the new day (creating a one-time 6-day interval) and continue weekly from there