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Research suggests KPV may influence inflammatory pathways such as NF-kB and MAPK signaling and may reduce production of certain pro-inflammatory cytokines in experimental models

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(87) utilized a two-by-two factorial design over 4.6 years with 25,871 middle-aged or older adults, including 1,032 with a history of probable migraine, and found that neither vitamin D nor marine omega-3 PUFAs supplementation affected migraine frequency or severity compared to a placebo

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