Several barriers must be overcome when developing orally administered peptides with a molecular weight above 1,000 Da, including enzymatic degradation in the GI tract, pH-induced conformational changes, limited permeability of the intestinal membrane, and variable GI tract absorption rates [2, 3, 42, 43]
doi: 10.1016/j.ijcard.2011.09.039 260 McGuireDKShihWJCosentinoFCharbonnelBCherneyDZIDagogo-JackSet al
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