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05 Severe nausea or vomiting during escalation Published trials held the dose rather than skipping titration steps, commonly maintaining the current dose for an additional 4 weeks before stepping up

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The tetracycline class had enrichment of the resistance genes tetA , tetB , tetC , tetK and tetL in visit 3, however, according to the CARD database, these genes were also present in many Gram-negative (e.g., tetA , tetB , tetC , tetK and tetL ) and Gram-positive (e.g., tetK and tetL only) bacteria that were not exclusively present in the Enterobacteriaceae family

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